| Autor: |
Jingu, Keiichi, Ito, Kengo, Sato, Kiyokazu, Umezawa, Rei, Yamamoto, Takaya, Takahashi, Noriyoshi, Suzuki, Yu, Kishida, Keita, Omata, So, Harada, Hinako, Seki, Yasuhiro, Chiba, Nanae, Kadoya, Noriyuki |
| Předmět: |
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| Zdroj: |
Journal of Radiation Research; Jan2024, Vol. 65 Issue 1, p87-91, 5p |
| Abstrakt: |
The purpose of this study was to show the safety of volumetric modulated arc therapy (VMAT) with deep inspiration breath-hold (DIBH) in hypofractionated radiotherapy for left-sided breast cancer after breast-conserving surgery in a clinical setting. Twenty-five Japanese women, aged 20–59 years, who were enrolled in this prospective non-inferiority study received VMAT under the condition of DIBH with 42.4 Gy/16 fractions for whole-breast irradiation (WBI) ± boost irradiation for the tumor bed to show the non-inferiority of VMAT with DIBH to conventional fractionated WBI with free breathing. The primary endpoint was the rate of occurrence of radiation dermatitis of Grade 3 or higher or pneumonitis of Grade 2 or higher within 6 months after the start of radiotherapy. This study was registered with UMIN00004321. All of the enrolled patients completed the planned radiotherapy without interruption. The evaluation of adverse events showed that three patients (12.0%) had Grade 2 radiation dermatitis. There was no other Grade 2 adverse event and there was no patient with an adverse event of Grade 3 or higher. Those results confirmed our hypothesis that the experimental treatment method is non-inferior compared with our historical results. There was no patient with locoregional recurrence or metastases. In conclusion, VMAT under the condition of DIBH in hypofractionated radiotherapy for left-sided breast cancer after breast-conserving surgery can be performed safely in a clinical setting. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
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