| Autor: |
Wojciechowska, Małgorzata, Chęcińska-Maciejewska, Zuzanna, Pruszyńska-Oszmałek, Ewa, Ciborek, Andrzej, Gibas-Dorna, Magdalena, Rękas-Dudziak, Anna, Krauss, Hanna, Kołodziejski, Paweł A. |
| Předmět: |
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| Zdroj: |
Journal of Pre-Clinical & Clinical Research; 2023, Vol. 17 Issue 3, p149-156, 8p |
| Abstrakt: |
Introduction and objective. Gestational diabetes mellitus (GDM) is a metabolic disease affecting an increasing number of women. The disease not only affects the health of mothers, but may also contribute to metabolic problems in children, both at the stage of foetal life and in the future, including increasing the risk of obesity or type 2 diabetes. Therefore, it is important to conduct research to get closer to fully defining the problem and developing therapies or methods of preventing GDM. Materials and method. The study used umbilical cord blood from 540 women (260-healthy and 280 - GDM) and commercially available ELISA and RIA tests to investigate the interaction between leptin, ghrelin (active and total) and insulin in cord blood, and its correlation with anthropometric parameters of newborns as well as pregnancy week on the day of delivery, weight, BMI and growth of mothers. Results. It was found that in healthy mothers there were statistically significant correlations between maternal pre-pregnancy weight in relation to leptin (positive) and glucose (negative), a positive correlation between active ghrelin concentration and gestational week at delivery, and a positive level of leptin to the chest circumference of newborns, and a negative of glucose levels to the chest circumference of newborns at birth in the healthy group. In the GDM group, a positive correlation was found of total ghrelin to the abdominal circumference of the newborns at birth, and a positive of leptin concentration and thigh circumference of the newborns Conclusions. It was concluded that altered hormonal profiles during the prenatal period may have long-term consequences for the health of children. The study also indicated the need for further research in this area to better understand the causes and consequences of GDM r. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
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