The synthesis of indolizin-1-ylphosphonates via the reaction of ethynylphosphonates with pyridinium methylides.

Autor:	Filippov, Igor R., Sonina, Alina A., Vorob'ev, Aleksey Yu.
Předmět:	HIGH temperatures LOW temperatures TEMPERATURE
Zdroj:	Chemistry of Heterocyclic Compounds; Dec2023, Vol. 59 Issue 11/12, p786-792, 7p
Abstrakt:	The reaction of diethyl ethynyl- and 2-phenylethynylphosphonates with pyridinium methylides generated in situ from phenacyl- and 2-ethoxy-2-oxoethylpyridinium salts by the action of a base was studied. As a result of the reaction, the corresponding diethyl indolizin-1-ylphosphonates were formed. In this case, diethyl ethynylphosphonate demonstrated higher reactivity and underwent a reaction at room temperature in the K2CO3–MeCN system, while reactions with 2-phenylethynylphosphonate proceeded at elevated temperatures and resulted in lower indolizine yields. [ABSTRACT FROM AUTHOR]
Databáze:	Complementary Index
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