| Autor: |
Strous, Maud T. A., Molenaar, Charlotte J. L., Franssen, Ruud F. W., van Osch, Frits, Belgers, Eric, Bloemen, Johanne G., Slooter, Gerrit D., Melenhorst, Jarno, Heemskerk, Jeroen, de Bruïne, Adriaan P., Janssen-Heijnen, Maryska L. G., Vogelaar, F. Jeroen |
| Zdroj: |
British Journal of Cancer; Feb2024, Vol. 130 Issue 2, p251-259, 9p |
| Abstrakt: |
Background: In treatment of colon cancer, strict waiting-time targets are enforced, leaving professionals no room to lengthen treatment intervals when advisable, for instance to optimise a patient's health status by means of prehabilitation. Good quality studies supporting these targets are lacking. With this study we aim to establish whether a prolonged treatment interval is associated with a clinically relevant deterioration in overall and cancer free survival. Methods: This retrospective multicenter non-inferiority study includes all consecutive patients who underwent elective oncological resection of a biopsy-proven primary non-metastatic colon carcinoma between 2010 and 2016 in six hospitals in the Southern Netherlands. Treatment interval was defined as time between diagnosis and surgical treatment. Cut-off points for treatment interval were ≤35 days and ≤49 days. Findings: 3376 patients were included. Cancer recurred in 505 patients (15.0%) For cancer free survival, a treatment interval >35 days and >49 days was non-inferior to a treatment interval ≤35 days. Results for overall survival were inconclusive, but no association was found. Conclusion: For cancer free survival, a prolonged treatment interval, even over 49 days, is non-inferior to the currently set waiting-time target of ≤35 days. Therefore, the waiting-time targets set as fundamental objective in current treatment guidelines should become directional instead of strict targets [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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