Autor: |
Guo, Bo, Li, Peili, Qin, Bingyu, Wang, Shanmei, Zhang, Wenxiao, Shi, Yuan, Yang, Jianxu, Niu, Jingjing, Chen, Shifeng, Chen, Xiao, Cui, Lin, Fu, Qizhi, Guo, Lin, Hou, Zhe, Li, Hua, Li, Xiaohui, Liu, Ruifang, Liu, Xiaojun, Mao, Zhengrong, Niu, Xingguo |
Předmět: |
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Zdroj: |
BMC Infectious Diseases; 1/22/2024, Vol. 24 Issue 1, p1-8, 8p |
Abstrakt: |
Objective: This study aimed to explore the characteristics of carbapenem-resistant Enterobacterales (CRE) patients in the intensive care unit (ICU) in different regions of Henan Province to provide evidence for the targeted prevention and treatment of CRE. Methods: This was a cross-sectional study. CRE screening was conducted in the ICUs of 78 hospitals in Henan Province, China, on March 10, 2021. The patients were divided into provincial capital hospitals and nonprovincial capital hospitals for comparative analysis. Results: This study involved 1009 patients in total, of whom 241 were CRE-positive patients, 92 were in the provincial capital hospital and 149 were in the nonprovincial capital hospital. Provincial capital hospitals had a higher rate of CRE positivity, and there was a significant difference in the rate of CRE positivity between the two groups. The body temperature; immunosuppressed state; transfer from the ICU to other hospitals; and use of enemas, arterial catheters, carbapenems, or tigecycline at the provincial capital hospital were greater than those at the nonprovincial capital hospital (P < 0.05). However, there was no significant difference in the distribution of carbapenemase strains or enzymes between the two groups. Conclusions: The detection rate of CRE was significantly greater in provincial capital hospitals than in nonprovincial capital hospitals. The source of the patients, invasive procedures, and use of advanced antibiotics may account for the differences. Carbapenem-resistant Klebsiella pneumoniae (CR-KPN) was the most prevalent strain. Klebsiella pneumoniae carbapenemase (KPC) was the predominant carbapenemase enzyme. The distributions of carbapenemase strains and enzymes were similar in different regions. [ABSTRACT FROM AUTHOR] |
Databáze: |
Complementary Index |
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