| Autor: |
Tan, Lennart, Bansal, Goldy, Yeung, Cecilia CS, Yin, Jane, Dave, Bhavana J., Konnick, Eric, Wu, David, Naresh, Kikkeri N |
| Předmět: |
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| Zdroj: |
Annals of Hematology; Feb2024, Vol. 103 Issue 2, p667-669, 3p |
| Abstrakt: |
This letter, published in the Annals of Hematology, discusses a case of leukemic non-nodal mantle cell lymphoma (LNN-MCL) in a woman in her 70s. LNN-MCL is characterized by abnormal B-cells in the blood and bone marrow, without significant lymphadenopathy. Typically, LNN-MCL is associated with the overexpression of cyclin D1 protein, but in this case, the patient had a rearrangement of the CCND3 gene instead. The authors highlight the challenges in diagnosing cyclin D1-negative LNN-MCL, as it can be mistaken for other types of lymphoma. The case also revealed mutations in TP53 and ARID1A genes, indicating disease progression. This is the first reported case of MCL involving a cavernous hemangioma. [Extracted from the article] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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