| Autor: |
Dourdan, Juliette, Rouzier, Florian, Huynh, Thanh Thao, Bricaud, Sullivan, Nourry, Arnaud, Guillarme, Stéphane |
| Předmět: |
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| Zdroj: |
New Journal of Chemistry; 2/7/2024, Vol. 8 Issue 4, p1476-1480, 5p |
| Abstrakt: |
Highly stereoselective 1,3-dipolar cycloaddition allowed the synthesis of the original stable TN antigen mimic presenting a constraint on the amino acid part. Two main conformations of the GalNAc moiety were detected by molecular modelling and NMR. A ligand/protein interaction study was performed by saturation transfer difference NMR analyses using two GalNAc-specific model lectins highlighting that the constrained C-glycoside analog was recognized by these proteins as well as the TN antigen derivative. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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