| Abstrakt: |
A recent study conducted by researchers at Northwestern University Feinberg School of Medicine in Chicago, Illinois, explores the spatial relationship and functional interaction of immune cells in glioblastoma (GBM), a type of brain cancer. The study found that B and T cells form clusters within the GBM microenvironment, suggesting the potential for immune synapses. However, GBM-infiltrating B cells suppress the activation of CD8+ T cells. To overcome this immunosuppression, the researchers developed antigen-presenting B cells called BVax, which showed improved antigen cross-presentation potential and enhanced CD8 T cell activation and proliferation compared to naive B cells. The findings suggest that BVax and dendritic cells (DCs) can generate distinctive CD8+ T cells, which could have multiple applications in cellular vaccine development. [Extracted from the article] |
