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| Zdroj: |
Genomics & Genetics Weekly; 1/26/2024, p279-279, 1p |
| Abstrakt: |
Researchers at the Beijing Institute of Radiation Medicine conducted a study to investigate the delayed effects of radiation on the central nervous system and bone system in C57BL/6J mice. The study aimed to provide a suitable mouse model for radiation-induced delayed reactions and identify potential targets for drug development related to radiation injury prevention and treatment. The results showed that exposure to radiation led to a decrease in spatial memory ability and activity in mice, with cognitive and motor functions gradually recovering over time. The study also found that bone density decreased due to an increase in osteoclast number, and brain injury was linked to the down-regulation of certain proteins. The mechanism of cognitive and activity damage was mainly related to oxidative stress and apoptosis induced by DNA damage. The study concluded that the damage caused by a specific dose of radiation was relatively stable and could be used as a model for radiation mechanism research and anti-radiation medicine screening. [Extracted from the article] |
| Databáze: |
Complementary Index |
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