Biodegradable Microparticles with Encapsulated Anti-Inflammatory Peptide Ingramon.

Autor:	Marmiy, N. V., Arefieva, T. I., Esipov, D. S., Tashlitsky, V. N., Kozhokar, U. S., Ovchinnikov, M. V., Radyukhina, N. V., Sidorova, M. V.
Předmět:	PEPTIDES GLYCOLIC acid LACTIC acid MICROSPHERES PHARMACOPOEIAS
Zdroj:	Pharmaceutical Chemistry Journal; Nov2023, Vol. 57 Issue 8, p1290-1297, 8p
Abstrakt:	A technique for encapsulating the anti-inflammatory dodecapeptide ingramon into microspheres of a biodegradable copolymer of lactic and glycolic acids (PLGA) to provide prolonged release of the peptide for up to 28 d is presented. The technique makes it possible to achieve >90% encapsulation efficiency and is suitable for producing an injectable suspension that meets the requirements of the State Pharmacopoeia of the Russian Federation. The peptide distribution inside the obtained microspheres and its release kinetics were characterized. A tendency toward suppression of JE/CCL2-dependent monocyte migration was revealed in mice with preliminary (7 d before the experiment) administration of ingramon-depot. [ABSTRACT FROM AUTHOR]
Databáze:	Complementary Index
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