| Autor: |
Latha, H. Aparna, Kommalapati, Vatsalya, Naag, Sushma, Kalyan, Shoba, Vidya, Karanam Satyanarayana, Vidhyadhari, Pavani |
| Předmět: |
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| Zdroj: |
Oral & Maxillofacial Pathology Journal; Jul-Dec2023, Vol. 14 Issue 2, p204-207, 4p |
| Abstrakt: |
Introduction: Viral infection contributes significantly to the global cancer burden. Cancer is a disease that has a molecular basis. The first regulatory factors in this biological process are proto-oncogenes. They act as growth factors by transmitting signals. Changes to these genes, known as oncogenes, result in the appearance of cancer cells. Chromosomal translocation, point mutation, and gene amplification are the activation processes that lead to proto-oncogenes. The path from basic viral infection to tumorigenesis is complicated by factors such as immune complications, cellular mutations, and exposure to other cancerous agents. Hepatitis B virus (HBV), Hepatitis C virus (HCV), Epstein-Barr virus (EBV), Human papillomavirus (HPV), Kaposi's sarcoma herpes virus (KSHV), and Human T lymphotrophic virus 1 are the viruses involved in the development of human cancer (HTLV-1). Materials and Methods: Scientific databaes were searched for the literature and relevant articles were selected for review. Conclusion: This review article summarises knowledge about human oncogenic viruses and the molecular mechanisms that lead to tumorigenesis in humans, cancer hallmarks, host and environmental co-factors that contribute to the biology of multistep oncogenesis mediated by established human oncoviruses, and oncogenic DNA and RNA viruses. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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