Protective Effect of Resveratrol Against Renal Oxidative Stress in Cholestasis.

Autor:	Ara, Cengiz, Karabulut, Aysun Bay, Kirimlioglu, Hale, Coban, Sacit, Ugras, Murat, Kirimliglu, Vedat, Yilmaz, Sezai
Předmět:	RESVERATROL OXIDATIVE stress CHOLESTASIS BILE duct surgery INTRAPERITONEAL injections KIDNEY diseases
Zdroj:	Renal Failure; Jul2005, Vol. 27 Issue 4, p435-440, 6p, 2 Charts
Abstrakt:	Background/aims. This experimental study was designed to evaluate histological changes of the kidney and renal tissue levels of malondialdehyde (MDA), reduced glutathione (GSH), and nitric oxide (NO) and the effect of resveratrol on these metabolites after bile duct ligation in rats. Methods. Secondary biliary cirrhosis was induced by bile duct ligation for 28 days. Swiss albino rats were divided into three groups. Group 1: Sham ( n = 7), Group 2: Bile duct ligation ( n = 7), Group 3: Bile duct ligation plus resveratrol ( n = 7). Bile duct ligation (BDL) plus resveratrol group received 10 mgr/kg dose of resveratrol intraperitoneally daily throughout 28 days. Kidney tissues were harvested to determine the tissue levels of MDA, GSH, and NO activity. Liver and kidney tissues were removed for light microscopic evaluation. Results. Cholestasis was determined by biochemical and pathologic examination. In the resveratrol-treated rats, levels of MDA were significantly lower than those of the BDL group ( p [ABSTRACT FROM AUTHOR]
Databáze:	Complementary Index
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