| Autor: |
Yanar, Karolin, Atayik, Mehmet, Horozoğlu, Cem, Demirkol, Şeyda, Simsek, Bahadir, Verim, Aysegul, Küçükhüseyin, Özlem, Aydın, Seval, Yaylım, İlhan, Çakatay, Ufuk |
| Předmět: |
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| Zdroj: |
Journal of Cancer Research & Therapeutics; Oct-Dec2023, Vol. 19 Issue 7, p1781-1787, 7p |
| Abstrakt: |
Background: Intercellular adhesion molecule-1 (ICAM-1) is a surface glycoprotein important for tumor invasion and angiogenesis. The present research is conducted to investigate whether specific gene polymorphism of ICAM-1 K469E (rs5498) and plasma redox status could be associated with laryngeal cancer (LC) development. Since there is no clear evidence which investigates the relationship between ICAM-1 polymorphism and ROS-mediated plasma protein oxidation in LC, our study is the first significant contribution for investigating the relationship. Methods: The study covered patients with primary LC and their age-matched healthy control subjects. Evaluation of ICAM-1 K469E (rs5498) gene polymorphism was performed by polymerase chain reaction-restriction fragment length polymorphism. Plasma redox status was assessed with spectrophotometric methods. Results: In the current paper, we found that LC patients with GG genotype had a decreasing trend for the plasma oxidative damage biomarker levels when compared with all allele genotypes (AA and AG). Conclusion: We concluded that G allele of the ICAM-1 K469E gene plays a significant role in the optimal regulation of plasma redox homeostasis in patients with LC. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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