| Autor: |
Massaro, Marina, Cinà, Giuseppe, Borrego‐Sánchez, Ana, Sainz‐Díaz, C. Ignacio, Viseras‐Iborra, César, Sánchez‐Espejo, Rita, de Melo Barbosa, Raquel, Leone, Federica, Pibiri, Ivana, Noto, Renato, Riela, Serena |
| Předmět: |
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| Zdroj: |
ChemPlusChem; Jan2024, Vol. 89 Issue 1, p1-10, 10p |
| Abstrakt: |
Nowadays the use of hydrogels for biomedical purposes is increasing because of their interesting features that allow the development of targeted drug delivery systems. Herein, hydrogel based on Laponite® (Lap) clay mineral as gelator and cucurbit[6]uril (CB[6]) molecules were synthetized for the delivery of flufenamic acid (FFA) for potential topical application. Firstly, the interaction between CB[6] and FFA was assessed by UV‐vis spectroscopic measurements and molecular modeling calculations. Then, the obtained complex was used as filler for Lap hydrogel (Lap/CB[6]/FFA). The properties of the hydrogel in terms of viscosity and, self‐repair abilities were investigated; its morphology was imaged by scanning electron and polarized optical microscopies. Furthermore, the changes in the hydrodynamic radii and in the colloidal stability of CB[6]/Lap mixture were investigated in terms of translational diffusion from dynamic light scattering and ζ‐potential measurements. Finally, the kinetic in vitro release of FFA, from Lap/CB[6]/FFA hydrogel, was studied in a medium mimicking the pH of skin and the obtained results were discussed both by an experimental point of view and by molecular modeling calculations. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
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