| Autor: |
Grave, Erick Cruz, Loehfelm, Thomas, Corwin, Michael T., Zepeda, Joseph, Bath, Harjot K., Dhaliwal, Sandeep, Yazdanfar, Maryam, Bowlus, Christopher L. |
| Předmět: |
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| Zdroj: |
Abdominal Radiology; Jan2024, Vol. 49 Issue 1, p60-68, 9p |
| Abstrakt: |
Background: Primary sclerosing cholangitis (PSC) is a cholestatic liver disease that progresses to cirrhosis and liver failure. The Anali and Amsterdam scores are based upon imaging features on MRI and ERCP, respectively. Aims: We aimed to compare the interobserver variability and performances of these scores. Methods: Patients with PSC with at least 1 MRCP were included. Images were independently scored by 2 experts. Agreement and prognostic performance with a primary end point of hepatic decompensation was assessed. Results: Fifty-nine patients were included (67.8% male, 86.4% IBD). Interobserver agreement for the Anali and Amsterdam scores were moderate (k = 0.49; 95% CI 0.35–0.64 and k = 0.43; 95% CI 0.30–0.56, respectively). Among the Anali components, dysmorphy (caudate/right lobe ratio > 0.9) had fair agreement (k = 0.37; 95% CI 0.14–0.60) and portal hypertension (k = 0.64, 95% CI 0.32–0.89) and intrahepatic dilation (k = 0.70; 95% CI 0.53–0.87) had substantial agreement. The Amsterdam extrahepatic and intrahepatic scores had fair agreement (k = 0.38; 95% CI 0.23–0.52) and moderate agreement (k = 0.50; 95% CI 0.34–0.67), respectively. Anali score (HR 5.90, 95% CI 1.64–21.21), total bilirubin (HR = 3.23; 95% Cl 1.06–9.91), and age (HR = 1.05; 95% CI 1.00–1.11) were independent predictors of hepatic decompensation. Mayo risk score and Anali score had good discriminative ability with c-statistics of 0.78 (CI 0.59–0.96) and 0.76 (CI 0.56–0.91). Anali score remained an independent predictor after adjusting for Mayo risk score. Conclusion: Anali score adds additional predictive value for hepatic decompensation in patients with PSC. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
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