| Autor: |
Gouw, Launce G., Reading, N. Scott, Jenson, Stephen D., Lim, Megan S., Elenitoba-Johnson, Kojo S. J. |
| Předmět: |
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| Zdroj: |
British Journal of Haematology; May2005, Vol. 129 Issue 4, p531-533, 3p |
| Abstrakt: |
We have studied the expression of RHOF, a member of the Rho-GTPase family, in an array of lymphoid cells and tissues. Previous microarray studies demonstrated RHOF upregulation in a subset of transformed follicular lymphomas. Real-time quantitative polymerase chain reaction evaluated RHOF expression in lymphocyte subpopulations, and normal and malignant lymphoid tissue. Cells and tissues of B-cell origin expressed higher RHOF levels than their T-cell counterparts. Neoplastic cells and tissues of B-cell origin expressed higher levels of RHOF than their benign cellular counterparts. Relatively elevated levels of RHOF were seen in lymphomas derived from germinal centre origin. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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