| Autor: |
Lu, Jin, He, Yibo, Yang, Yanfang, Zhong, Xuejing, Chen, Shaowen, Wu, Bo, Pan, Yuxiong, Wang, Yizhang, Xiu, Jiaming, Kang, Yu, Liu, Jin, Liu, Yong, Chen, Shiqun, Chen, Kaihong, Chen, Liling |
| Předmět: |
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| Zdroj: |
Clinical Interventions in Aging; Dec2023, Vol. 18, p2053-2061, 9p |
| Abstrakt: |
Background: The association between uric acid (UA) and contrast-induced acute kidney injury (CI-AKI) following coronary angiography (CAG) has been established. However, whether the association would vary with age remained undetermined.Methods: We performed the retrospective analysis based on the Cardio-renal Improvement II study, (ClinicalTrials.gov NCT05050877), which enrolled consecutive patients undergoing coronary angiography in 5 teaching hospitals in China from 2007 to 2020. The primary outcome was CI-AKI defined as the rise of serum creatinine (SCr) ≥ 0.5 mg/dL or 25% compared with the baseline value within 48 hours following CAG. The effect of age on the association between uric acid and CI-AKI was assessed by the logistic regression model.Results: A total of 36,550 patients (mean age 63.08± 5.6-year-old, 41.7% men) were included in the study. After adjusting for the confounders, the risk of CI-AKI between each quartile of uric acid was insignificant in the young group. In patients of the middle group, lower UA was associated with a lower risk of CI-AKI while higher UA was associated with a higher risk (Q1 OR: 0.853, 95% CI: 0.734– 0.993; Q4 OR: 1.797, 95% CI: 1.547– 2.09). In patients of the elder group, lower and higher UA were both associated with a higher risk of CI-AKI (Q1 OR: 1.247, 95% CI: 1.003– 1.553; Q4 OR: 1.688, 95% CI: 1.344– 2.124). The restricted cubic spline indicated a non-linear association between UA and CI-AKI in middle and elder age groups but a linear association in the young age group.Conclusion: The association between uric acid and CI-AKI vary in patients of different age. Patients with elder age should maintain a middle level of uric acid while patients with middle age should consider a lower level of uric acid to reduce the risk of CI-AKI. The level of UA was an insignificant risk factor for CI-AKI in young patients. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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