| Autor: |
Traut, Caroline C, Jones, Joyce L, Sanders, Renata A, Clark, Laura R, Hamill, Matthew M, Stavrakis, Georgia, Sop, Joel, Beckey, Tyler P, Keller, Sara C, Gilliams, Elizabeth A, Cochran, Willa V, Laeyendecker, Oliver, Manabe, Yukari C, Mostafa, Heba H, Thomas, David L, Hansoti, Bhakti, Gebo, Kelly A, Blankson, Joel N |
| Předmět: |
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| Zdroj: |
Journal of Infectious Diseases; 1/15/2024, Vol. 229 Issue 1, p54-58, 5p |
| Abstrakt: |
Orthopoxvirus-specific T-cell responses were analyzed in 10 patients who had recovered from Mpox including 7 people with human immunodeficiency virus (PWH). Eight participants had detectable virus-specific T-cell responses, including a PWH who was not on antiretroviral therapy and a PWH on immunosuppressive therapy. These 2 participants had robust polyfunctional CD4+ T-cell responses to peptides from the 121L vaccinia virus (VACV) protein. T-cells from 4 of 5 HLA-A2–positive participants targeted at least 1 previously described HLA-A2–restricted VACV epitope, including an epitope targeted in 2 participants. These results advance our understanding of immunity in convalescent Mpox patients. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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