| Autor: |
Bonacina, Erika, Garcia‐Manau, Pablo, López, Monica, Caamiña, Sara, Vives, Àngels, Lopez‐Quesada, Eva, Ricart, Marta, Maroto, Anna, de Mingo, Laura, Pintado, Elena, Castillo‐Ribelles, Laura, Martín, Lourdes, Rodriguez‐Zurita, Alicia, Garcia, Esperanza, Pallarols, Mar, Vidal‐Sagnier, Laia, Teixidor, Mireia, Orizales‐Lago, Carmen, Pérez‐Gomez, Adela, Ocaña, Vanesa |
| Předmět: |
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| Zdroj: |
BJOG: An International Journal of Obstetrics & Gynaecology; Feb2024, Vol. 131 Issue 3, p334-342, 9p |
| Abstrakt: |
Objective: To assess whether aspirin treatment can be discontinued in pregnancies with normal uterine artery pulsatility index (≤90th percentile) at 24–28 weeks. Design: Post‐hoc analysis of a clinical trial. Setting: Nine maternity hospitals in Spain. Population or Sample: Pregnant individuals at high risk of pre‐eclampsia at 11–13 weeks and normal uterine artery Doppler at 24–28 weeks. Methods: All participants received treatment with daily aspirin at a dose of 150 mg. Participants were randomly assigned, in a 1:1 ratio, either to continue aspirin treatment until 36 weeks (control group) or to discontinue aspirin treatment (intervention group), between September 2019 and September 2021. In this secondary analysis, women with a UtAPI >90th percentile at 24–28 weeks were excluded. The non‐inferiority margin was set at a difference of 1.9% for the incidence of preterm pre‐eclampsia. Main outcome measures: Incidence of preterm pre‐eclampsia. Results: Of the 1611 eligible women, 139 were excluded for UtAPI >90th percentile or if UtAPI was not available. Finally, 804 were included in this post‐hoc analysis. Preterm pre‐eclampsia occurred in three of 409 (0.7%) women in the aspirin discontinuation group and five of 395 (1.3%) women in the continuation group (−0.53; 95% CI −1.91 to 0.85), indicating non‐inferiority of aspirin discontinuation. Conclusions: Discontinuing aspirin treatment at 24–28 weeks in women with a UtAPI ≤90th percentile was non‐inferior to continuing aspirin treatment until 36 weeks for preventing preterm pre‐eclampsia. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
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