Unexplained Serum Iron Elevation After Neoadjuvant Chemotherapy in Pancreatic Cancer.

Autor: Lili Zhan, Xinjian Cai, Yanan Zhang
Předmět:
Zdroj: Clinical Laboratory; 2024, Vol. 70 Issue 1, p179-182, 4p
Abstrakt: Background: Pancreatic ductal adenocarcinoma (PDAC) is a malignant tumor originating from the epithelium of the pancreatic duct. Neoadjuvant chemotherapy FOLFIRINOX (a combination of oxaliplatin, irinotecan, and 5- fluorouracil/leucovorin) is considered to be the most effective regimen for patients with resected pancreatic cancer. Methods: This article reports a case of a pancreatic ductal adenocarcinoma patient who exhibited regular periodic fluctuations in the serum iron level during FOLFIRINOX. Results: It indicates that an unexplained increase in serum iron levels after each cycle of FOLFIRINOX is non-cell destructive and due to a reduction in iron consumption, after ruling out other potential causes. Conclusions: FOLFIRINOX in pancreatic cancer patients may cause an elevation of serum iron levels. [ABSTRACT FROM AUTHOR]
Databáze: Complementary Index