Aza‐Prins Cyclization on Ketones to Access Piperidines with Tetrasubstituted Carbon Stereocenters.

Autor: Bergounioux, Alexandre, Lhotellier, Romane, Roisnel, Thierry, Gouault, Nicolas, Argouarch, Gilles, Lalli, Claudia
Předmět:
Zdroj: Advanced Synthesis & Catalysis; 1/9/2024, Vol. 366 Issue 1, p31-35, 5p
Abstrakt: The aza‐Prins cyclization in presence of a variety of aliphatic, aromatic, and heterocyclic ketones is disclosed. The developed method allows an access to diverse C‐2 functionalized piperidines, bearing a tetrasubstituted or spiranic carbon stereocenter, in a range of 30 to 87% yields. When diastereomers were formed, the trans isomer was identified as the major product. [ABSTRACT FROM AUTHOR]
Databáze: Complementary Index