| Autor: |
Gaut, Daria, Oliai, Caspian, Boiarsky, Jonathan, Zhang, Shiliang, Salhotra, Amandeep, Azenkot, Tali, Kennedy, Vanessa E., Khanna, Vishesh, Olmedo Gutierrez, Karla, Shukla, Navika, Moskoff, Benjamin, Park, Gabriel, Afkhami, Michelle, Patel, Anand, Jeyakumar, Deepa, Mannis, Gabriel, Logan, Aaron C., Jonas, Brian A., Schiller, Gary |
| Předmět: |
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| Zdroj: |
Leukemia & Lymphoma; Jan2024, Vol. 65 Issue 1, p69-77, 9p |
| Abstrakt: |
The rate of MRD clearance in AML with standard consolidation chemotherapy is not well defined. A multi-institution retrospective analysis was performed on 107 consecutively treated AML patients in morphologic complete remission with detectable MRD post-induction therapy who received standard chemotherapy consolidation. In response to standard intermediate/high-dose cytarabine consolidation therapy, 26 of 60 patients (43.3%) with MRD threshold of detection of at least 0.1% converted to MRD-negative status (undetectable with assay used), and 6 of 47 patients (12.8%) with MRD threshold of detection > 0.1% converted to MRD-negative status. Multivariable logistic regression for patients with MRD threshold of detection of at least 0.1% showed that, when controlling for age, ELN risk category, dose of cytarabine, and use of a combination agent, treatment with 1 cycle of consolidation cytarabine versus ≥2 cycles decreased the odds of conversion of AML to MRD-negative (OR = 0.24, 95% CI 0.07–0.85, p = 0.03). [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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