| Autor: |
Srivastava, Amit, Thapa, Shobit, Chakdar, Hillol, Babele, Piyoosh Kumar, Shukla, Pratyoosh |
| Předmět: |
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| Zdroj: |
Critical Reviews in Biotechnology; Feb2024, Vol. 44 Issue 1, p63-77, 15p |
| Abstrakt: |
Cyanobacteria safeguard their photosynthetic machinery from oxidative damage caused by adverse environmental factors such as high-intensity light. Together with many photoprotective compounds, they contain myxoxanthophylls, a rare group of glycosidic carotenoids containing a high number of conjugated double bonds. These carotenoids have been shown to: have strong photoprotective effects, contribute to the integrity of the thylakoid membrane, and upregulate in cyanobacteria under a variety of stress conditions. However, their metabolic potential has not been fully utilized in the stress biology of cyanobacteria and the pharmaceutical industry due to a lack of mechanistic understanding and their insufficient biosynthesis. This review summarizes current knowledge on: biological function, genetic regulation, biotechnological production, and pharmaceutical potential of myxoxanthophyll, with a focus on strain engineering and parameter optimization strategies for increasing their cellular content. The summarized knowledge can be utilized in cyanobacterial metabolic engineering to improve the stress tolerance of useful strains and enhance the commercial-scale synthesis of myxoxanthophyll for pharmaceutical uses. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
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