| Abstrakt: |
A recent report from California State University Fullerton provides new insights into central nervous system agents. The study focused on acetylcholinesterase (AChE), an enzyme that breaks down the neurotransmitter acetylcholine. Inhibiting AChE is a therapeutic strategy for treating Alzheimer's disease, and the researchers synthesized and evaluated 46 donepezil-based analogs to better understand the structural requirements for inhibition. The study found that certain substitutions on the phenyl moiety of donepezil yielded potent AChE inhibitors, while polysubstitutions led to decreased inhibition potency. This research contributes to the development of potential treatments for Alzheimer's disease. [Extracted from the article] |
