| Abstrakt: |
A report from Xiamen Cardiovascular Hospital of Xiamen University in China discusses the role of the SLC12A family of cation-chloride cotransporters (CCCs) in pharmaceutical research. The CCCs are involved in cell volume regulation and ion homeostasis, and dysfunction of these transporters can lead to diseases. The report summarizes various techniques used to study CCCs, including assays that measure potassium substitutes, patch-clamp electrophysiology, and fluorescent dyes. The researchers also highlight compounds that target CCCs for disease treatments. This information may be useful for researchers studying genetic disorders and drug discovery methodologies. [Extracted from the article] |
