| Abstrakt: |
The compound Curcumin has many health benefits. Due to their benefits, curcumin molecules are now being developed into pharmaceuticals. However, there is a lack of information on the properties of curcumin compounds that can be used as pre-formulation data, preventing the production of pharmaceutical products based on curcuminoids. This study sought to determine and characterise the physical properties of curcumin to generate pre-formulation data for the development of curcumin-based pharmaceutical products. Differential scanning calorimetry (DSC), powder x-ray diffractometry (PXRD), scanning electron microscopy (SEM), zeta potential value measurement using a zeta potential analyzer (ZPA), tap density, proper density, and solubility tests in propylene glycol, PEG 400, glycerin, and sorbitol solvents were used to characterize the physical properties of curcumin. Curcumin has a compressibility index of 16.463%, a proper density of 1.116 g/mL, a melting point of 169.63°C, a particle morphology of long beams that are crystalline, a zeta potential value of -59 mV, and was readily soluble in PEG 400. According to the study's findings, the isolated curcumin has a long beam shape, is amorphous, incompressible, has a reasonable flow rate, is stable under heating, and does not readily agglomerate. [ABSTRACT FROM AUTHOR] |
