| Autor: |
Rode, Sonali, Umathe, Amrita, Udhoji, Prasad, Parate, Shailesh, Salankar, Harsh |
| Předmět: |
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| Zdroj: |
Journal of Cardiovascular Disease Research (Journal of Cardiovascular Disease Research); 2023, Vol. 14 Issue 12, p1981-1989, 9p |
| Abstrakt: |
Background: Drug-induced renal disease is one of the most frequent etiological causes contributing to acute renal failure and chronic kidney disease in the current clinical setting. Different medicines cause certain typical renal responses by direct toxicity and immunologic mechanism virtue. Aim: The purpose of this study was to evaluate the incidence and prevalence of drug-induced nephrotoxicity (DIN) among kidney disease patients in the central Indian population. Methods: 500 participants within a predetermined age range were screened for the study, and anthropometric and demographic data were collected over a period of 2 years. A total of 120 patients with drug-induced nephrotoxicity were studied. Half of the study participants were female and ranged in age from 30 to 70 years. Serum creatinine was measured and protein was analyzed using the dipstick method. The 4-variable modification of diet in renal disease (MDRD) equation and the Cockcroft-Gault equation adjusted for body surface area (CG-BSA) were used to estimate the glomerular filtration rate (GFR). Detailed drug history was jotted down for the subjects who were included in the study. Results: Using MDRD to measure GFR, 2.8% of patients had proteinuria with DIN in 6.3% of subjects (n=120). Using the CG-BSA approach, it was discovered that the DIN prevalence was 24%. It was shown that there was a strong correlation between DIN and gender, advanced age, smoking, diabetes, hypertension, and abdominal obesity. The most common drugs causing nephrotoxicity were nonsteroidal anti-inflammatory drugs (NSAIDs) followed by aminoglycosides, diuretics, and, anticancer drugs. Conclusion: DIN is a major causative factor (24%) responsible for kidney diseases. The stark discrepancy in DIN prevalence between the MDRD and CG-BSA equations indicates the need for improved methods of evaluating renal function in the people of central India. Additionally, the CG-BSA equations point to a similar requirement for improved metrics to evaluate renal function. NSAIDS because of their widespread use are the most common drugs leading to nephrotoxicity. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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