18 F-Fluoroethyl-L Tyrosine Positron Emission Tomography Radiomics in the Differentiation of Treatment-Related Changes from Disease Progression in Patients with Glioblastoma.

Autor: Manzarbeitia-Arroba, Begoña, Hodolic, Marina, Pichler, Robert, Osipova, Olga, Soriano-Castrejón, Ángel Maria, García-Vicente, Ana María
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Zdroj: Cancers; Jan2024, Vol. 16 Issue 1, p195, 12p
Abstrakt: Simple Summary: 18F-Fluoroethyl-L tyrosine radiomics are useful in the differentiation of true progression from treatment-related changes in patients with glioblastoma, offering relevant complementary information with respect to the reference standard magnetic resonance imaging. The follow-up of glioma patients after therapeutic intervention remains a challenging topic, as therapy-related changes can emulate true progression in contrast-enhanced magnetic resonance imaging. 18F-fluoroethyl-tyrosine (18F-FET) is a radiopharmaceutical that accumulates in glioma cells due to an increased expression of L-amino acid transporters and, contrary to gadolinium, does not depend on blood–brain barrier disruption to reach tumoral cells. It has demonstrated a high diagnostic value in the differentiation of tumoral viability and pseudoprogression or any other therapy-related changes, especially when combining traditional visual analysis with modern radiomics. In this review, we aim to cover the potential role of 18F-FET positron emission tomography in everyday clinical practice when applied to the follow-up of patients after the first therapeutical intervention, early response evaluation, and the differential diagnosis between therapy-related changes and progression. [ABSTRACT FROM AUTHOR]
Databáze: Complementary Index
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