Clinical, immunological, and microbiological analysis of the association between periodontitis and COVID-19: a case–control study.

Autor: Bemquerer, Larissa Marques, Oliveira, Sicília Rezende, de Arruda, José Alcides Almeida, Costa, Fernanda Pereira Delgado, Miguita, Lucyene, Bemquerer, Ana Luisa Marques, de Sena, Ana Carolina Velasco Pondé, de Souza, Alessandra Figueiredo, Mendes, Daniel Fajardo, Schneider, Ayda Henriques, Azevedo, Michelle de Campos Soriani, Travassos, Denise Vieira, Garlet, Gustavo Pompermaier, Cunha, Fernando de Queiroz, de Aguiar, Renato Santana, de Souza, Renan Pedra, Gomez, Ricardo Santiago, Spahr, Axel, Obregon-Miano, Fabian, Abreu, Lucas Guimarães
Předmět:
Zdroj: Odontology; Jan2024, Vol. 112 Issue 1, p208-220, 13p
Abstrakt: Purpose: Periodontitis and coronavirus disease (COVID-19) share risk factors and activate similar immunopathological pathways, intensifying systemic inflammation. This study investigated the clinical, immunological and microbiological parameters in individuals with COVID-19 and controls, exploring whether periodontitis-driven inflammation contributes to worsening COVID-19 endpoints. Methods: Case (positive RT-PCR for SARS-CoV-2) and control (negative RT-PCR) individuals underwent clinical and periodontal assessments. Salivary levels of TNF-α, IL-6, IL-1β, IL-10, OPG, RANKL, neutrophil extracellular traps, and subgingival biofilm were analyzed at two timepoints. Data on COVID-19-related outcomes and comorbidity information were evaluated from medical records. Results: Ninety-nine cases of COVID-19 and 182 controls were included for analysis. Periodontitis was associated with more hospitalization (p = 0.009), more days in the intensive care unit (ICU) (p = 0.042), admission to the semi-ICU (p = 0.047), and greater need for oxygen therapy (p = 0.042). After adjustment for confounders, periodontitis resulted in a 1.13-fold increase in the chance of hospitalization. Salivary IL-6 levels (p = 0.010) were increased in individuals with COVID-19 and periodontitis. Periodontitis was associated with increased RANKL and IL-1β after COVID-19. No significant changes were observed in the bacterial loads of the periodontopathogens Porphyromona gingivalis, Aggregatibacter actinomycetemcomitans, Tanerella forsythia, and Treponema denticola. Conclusions: Periodontitis was associated with worse COVID-19 outcomes, suggesting the relevance of periodontal care to reduce the burden of overall inflammation. Understanding the crosstalk between SARS-CoV-2 infection and chronic conditions such as periodontitis that can influence disease outcome is important to potentially prevent complications of COVID-19. [ABSTRACT FROM AUTHOR]
Databáze: Complementary Index
Externí odkaz: