| Autor: |
Rahimi, Atefeh, Moridi, Nastaran, Golestani, Amin, Anani-Sarab, Gholamreza, Salmani, Fatemeh, Yaqubi, Gholamhossein, Mesbahzadeh, Behzad, Jalalifar, Mohammad Ali, Malekaneh, Mohammad, Sajjadi, Seyed Mehdi |
| Předmět: |
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| Zdroj: |
Caspian Journal of Internal Medicine; Winter2024, Vol. 15 Issue 1, p101-108, 8p |
| Abstrakt: |
Background: Diabetic retinopathy (DR) is expanding to epidemic levels globally due to the progressing prevalence of diabetes mellitus (DM). In this study, the association between factor V Leiden (FVL), MTHFRC677T, and FXIIIVal34Leu polymorphisms and diabetic retinopathy was investigated in Eastern Iran. Methods: This case-control study enlisted the participation of 300 people (diabetic patients=100, diabetic retinopathy patients=100, healthy controls=100), and polymorphisms were examined by Tetra primer ARMS-PCR. Results: The frequency of FVL (p=0.294) and FXIIIVal34Leu (P=0.349) polymorphism showed no significant results between the genotype frequency in the mentioned groups. In contrast, MTHFRC677T SNP was significantly different in diabetic patients and controls (P=0.008). The MTHFRC677T polymorphism was found to be connected with increased systolic blood pressure in patients who had the TT genotype (130.96±11.92mm/Hg; P=0.011). Conclusion: Our study recommended that the MTHFRC677T polymorphism may offer to DR development. Studies with larger sample sizes and a wider spectrum of populations are authorized to verify this finding. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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