| Autor: |
Loginova, N. A., Loseva, E. V., Sarkisova, K. Yu., Kudrin, V. S. |
| Předmět: |
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| Zdroj: |
Journal of Evolutionary Biochemistry & Physiology; Nov2023, Vol. 59 Issue 6, p2005-2021, 17p |
| Abstrakt: |
Immunotherapy with interferon-α (IFN-α) is frequently associated with neuropsychiatric consequences, including depression. Mechanisms underlying adverse effects of IFN-α are not fully understood. This study was aimed to determine whether intranasal administration of IFN-α can provoke depression-like behavior in rats and whether overcrowding stress can interfere or amplify the effects of IFN-α. To achieve this aim, effects of human IFN-α in low (50 IU/kg) and medium (8000 IU/kg) doses on the forced swimming test behavior and monoamines and their metabolite content in the brain structures of Wistar rats housed in standard and overcrowding conditions were investigated. Depressive-like behavior (increased immobility) was observed in rats housed in standard conditions after treatment with both doses of human IFN-α, as well as in vehicle-treated rats housed in stressful, overcrowding conditions. In standard conditions, a low dose of IFN-α produced a subtle alteration in the metabolism of dopamine only in one of the brain structures analyzed (nucleus accumbens). The medium dose of IFN-α induced more drastic neurochemical alterations in a larger number of brain structures. Overcrowding led to some changes in monoamine and their metabolite levels similar to those observed after IFN-α treatment with the medium dose in the standard housing conditions. In the overcrowded conditions, in contrast to the standard ones, IFN-α treatment in both doses reduced depression-like behavior and normalized neurochemical alterations induced by overcrowding. The results suggest that the effect of IFN-α on depression-like behavior and brain neurochemistry depends on the ongoing emotional status of animals: whether they are in stressful (overcrowded) or non-stressful (normal) conditions. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
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