Evaluation of the ceftazidime/avibactam and meropenem susceptibility by MALDI-TOF MS directly from positive blood cultures.

Autor: Wilhelm, Camila Mörschbächer, Moreira, Natália Kehl, Inamine, Everton, Caierão, Juliana, Barth, Afonso Luís
Předmět:
Zdroj: European Journal of Clinical Microbiology & Infectious Diseases; Jan2024, Vol. 43 Issue 1, p171-175, 5p
Abstrakt: The purpose of this study was to evaluate the MBT-ASTRA to determine susceptibility to ceftazidime/avibactam (CZA) and meropenem (MEM) of Enterobacterales directly from positive blood cultures (BC). Bacterial suspension was incubated with antibiotic and analyzed by MALDI-TOF MS. The relative growth was calculated and cutoff values were determined to categorize isolates as "S," "I," and "R." Klebsiella spp. with CZA 20/8 mg/L and 1.5-h incubation presented 1 (5.9%) major discrepancy and 96.3% category agreement; other species required 2.5 h for 100% category agreement. For MEM, 4 mg/L and 1.5h were necessary, demonstrating 2 (6.67%) minor discrepancies and 93.3% categorical agreement. [ABSTRACT FROM AUTHOR]
Databáze: Complementary Index