| Autor: |
Minamijima, Yohei, Kuroda, Taisuke, Kamiya, Takahiro, Sone, Yu, Wakuno, Ai, Ito, Hideki, Nomura, Motoi, Leung, Gary Ngai‐Wa, Kinoshita, Kenji, Yamada, Masayuki |
| Předmět: |
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| Zdroj: |
Journal of Veterinary Pharmacology & Therapeutics; Jan2024, Vol. 47 Issue 1, p21-27, 7p |
| Abstrakt: |
This study aimed to evaluate the pharmacokinetics (PK) of tranexamic acid (TXA) in horses and estimate its irrelevant plasma and urine concentrations using the pharmacokinetic/pharmacodynamic (PK/PD) approach by applying the Pierre‐Louis Toutain model. TXA was intravenously administered to eight thoroughbred mares, and plasma and urine TXA concentrations were quantified by liquid chromatography/tandem mass spectrometry. The quantified data were used to calculate the PK parameters of TXA in horses. The plasma elimination curves were best‐fitted to a three‐compartment model. Using the Toutain model approach, irrelevant plasma and urine TXA concentrations were estimated to be 0.0206 and 0.997 μg/mL, respectively. The typical values of clearance, steady‐state volume of distribution, and steady‐state urine‐to‐plasma ratio were 0.080 L/kg/h, 0.86 L/kg, and 49.0, respectively. The obtained irrelevant concentrations will be useful for establishing relevant regulatory screening limits for effective control of TXA use in horse racing and equestrian sports. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
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