اثر فعالیت با شدت بیشینه بر سلولهای سیستم ایمنی موشهای صحرایی دیابتی.

Autor: اصغر نیک سرشت, شهرزاد فهرستی حق, کاوس صلح جو, حسین کارگر جهرمی
Předmět:
Zdroj: Journal of Jahrom University of Medical Sciences; Winter2012, Vol. 10 Issue 4, p49-54, 6p
Abstrakt: Introduction: Diabetes is a metabolic disorder that can be followed by a decrease in insulin secretion. Exercise is an important factor in the control of diabetes and is also effective on the immune system. The purpose of this study was to investigate the effect of exercise intensity on the number of immune cells in the peripheral blood of diabetic rats. Materials and Methods: In this experimental study, 28 white female Wistar rats with average weight of 260 ± 20 and age of 80 days were randomly divided into four groups with seven subjects: control, diabetic without exercise, diabetic with electric shock and diabetic with maximum exercise. After four weeks of running on a treadmill, the blood samples were collected and sent to the laboratory so as to determine the number of immune system cells in blood. Results: White blood cell counts in diabetic rats with maximum exercise showed that the lymphocyte count was increased significantly (P≤0.05) as compared with control and diabetic rats without exercise but the monocyte and neutrophil counts were decreased significantly (P≤0.05). Also, the eosinophil counts in diabetic rats with maximum exercise did not decrease significantly (P≤0.05) compared with diabetic rats without exercise. Conclusion: The results showed an increase in the lymphocytes count and a decrease in the monocytes and neutrophil counts of diabetic rats with maximum exercise compared with diabetic rats without exercise; the most and the least frequent cells were lymphocytes and eosinophil, respectively in diabetic rats with maximum exercise. [ABSTRACT FROM AUTHOR]
Databáze: Complementary Index