| Autor: |
محمد پوراحمدی, مریم باقری, حجت اله کریمی جشن, حسین کارگر جهرمی, صفر زارعی |
| Předmět: |
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| Zdroj: |
Journal of Jahrom University of Medical Sciences; Winter2012, Vol. 10 Issue 4, p29-34, 6p |
| Abstrakt: |
Introduction: Nowadays using herbal products as an alternative or supplement to contraceptive synthetic drugs is common. There are reports of anti-estrogenic effects of nettle resulting in sterility in mammals. We asked if hydro-alcoholic extract of the nettle root (Urtica diocia) could alter serum concentrations of hormones; gandotropins and testosterone, in adult male rats. Materials and Methods: 80 adult male rats were randomly divided into 8 groups of 10. Three groups received 300, 600 and 1000 mg/ kg body weight of hydro-alcoholic extract of nettle root intraperitoneally for 3 days to lethal dose.In remaing groups, one as control, another as sham, and three others received 75, 150, 300 mg/kg body weight for 20 days. The rats were then sacrificed and FSH and LH serum concentrations were determined by ELISA. Results: The nettle extract increased LH significantly (P<0.05), whereas the effect on FSH was variable and nonsignificant. The extract tended to increase testosterone serum concentration but did not reach significant level. Conclusion: Hydro-alcoholic extract of nettle root has a positive effect on LH hormone at the dose of 300 mg/kg body weight. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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