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| Zdroj: |
Genomics & Genetics Weekly; 1/12/2024, p1894-1894, 1p |
| Abstrakt: |
Researchers at the University of Lyon have conducted a study on nerve tissue proteins, specifically focusing on alpha-synuclein (aS) protein and its association with neurodegenerative diseases. The study utilized a transgenic mouse model to investigate the aggregation of aS and its resistance to proteinase K (PK) digestion. The researchers found that intracerebral inoculations of the transgenic mice with PK-resistant aS samples significantly shortened the incubation period before the development of paralysis, demonstrating the pathogenicity of the aggregated protein. The study also observed differences in the aggregation patterns of aS in mice co-expressing mutated amyloid precursor and presenilin 1 proteins. The findings highlight similarities between synucleinopathies and prion diseases. [Extracted from the article] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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