Researcher at Northwestern University Feinberg School of Medicine Releases New Study Findings on Bladder Cancer (Somatic mutations of MLL4/COMPASS induce cytoplasmic localization providing molecular insight into cancer prognosis and treatment).

Předmět:	SOMATIC mutation BLADDER cancer CANCER prognosis RESEARCH personnel CANCER treatment CANCER genetics
Zdroj:	Cancer Weekly; 1/9/2024, p701-701, 1p
Abstrakt:	A new study conducted by researchers at Northwestern University Feinberg School of Medicine explores the molecular mechanisms underlying bladder cancer. The study focuses on somatic mutations of the MLL4/COMPASS gene, which regulate gene expression and potentially function as tumor suppressors. The researchers found that these mutations alter the subcellular localization of the MLL4 protein, resulting in loss-of-function in the nucleus and gain-of-function in the cytoplasm. The study suggests that cytoplasmic MLL4 could serve as a biomarker for bladder cancer and other diseases associated with MLL4 truncation mutations. [Extracted from the article]
Databáze:	Complementary Index
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