| Autor: |
Kagihara, Jaclyn E., Goyes, Daniela, Rabiee, Atoosa |
| Zdroj: |
Current Hepatology Reports; Dec2023, Vol. 22 Issue 4, p252-262, 11p |
| Abstrakt: |
Purpose of Review: Porto-sinusoidal vascular disease (PSVD) refers to a group of vascular diseases of the liver with lesions encompassing the portal venules and sinusoids, irrespective of portal pressure measurements and the presence or absence of cirrhosis. This article aims to provide an update on the pathologic, clinical, diagnostic, and therapeutic aspects of this underrecognized disease. Recent Findings: The diagnosis of PSVD requires a liver biopsy. Specific histology findings include nodular regenerative hyperplasia, obliterative portal venopathy or portal vein stenosis, and incomplete septal fibrosis/cirrhosis. The natural history of PSVD has not been elucidated, and screening guidelines for sequalae such as portal hypertension or portal vein thrombosis and the outcome of liver transplantation in these patients are unclear. Summary: Patients who have signs of portal hypertension despite unremarkable work-up for portal vein thrombosis and cirrhosis should be actively evaluated for PSVD. A heightened awareness of PSVD as a novel clinical entity should facilitate further collaborative studies and investigations. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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