Autor: |
Sunchu, Prabhakar, Gaurrand, Sandrine, Lambert, Émilie, Guillemont, Jérôme, Beigelman, Leonid, Brioche, Julien, Piettre, Serge R. |
Předmět: |
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Zdroj: |
European Journal of Organic Chemistry; 1/2/2024, Vol. 27 Issue 1, p1-6, 6p |
Abstrakt: |
Derivatives of 2'‐O‐4'‐C‐Ethylene‐bridged Nucleic Acid (ENA) monomer, a nucleoside used in the preparation of antisense modified oligonucleotides and featuring an alkyl group in position 7', are stereoselectively produced in nine steps from commercially available 3‐O‐benzyl‐4‐(hydroxymethyl)‐1,2‐O‐isopropylidene‐alpha‐D‐ribofuranose. The synthesis relies on a sequence of reactions involving a Tebbe olefination, a key ring‐closing metathesis, and an enol ether reduction. [ABSTRACT FROM AUTHOR] |
Databáze: |
Complementary Index |
Externí odkaz: |
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