Synthesis of Alkaloids and Compounds Containing the 3,4‐Benzomorphan Scaffold.

Autor: Rodríguez, Laura G., Bonjoch, Josep, Bradshaw, Ben
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Zdroj: European Journal of Organic Chemistry; 1/2/2024, Vol. 27 Issue 1, p1-26, 26p
Abstrakt: Several natural products, bearing an embedded hexahydro‐2,6‐methano‐1‐benzazocine framework (3,4‐benzomorphan) – a heterocyclic regioisomer of the 6,7‐benzomorphan substructure found in morphine alkaloids, have therapeutic potential for a variety of diseases. Biogenesis, biosynthetic approaches, and total syntheses of alkaloids or synthetic azapolycyclic compounds featuring the aforementioned azatricyclic ring system (i. e. a 3,4‐benzomorphan scaffold) are reviewed. [ABSTRACT FROM AUTHOR]
Databáze: Complementary Index