| Autor: |
El Mannoubi, Ines, Bashir, Seham Hassan, Alghamdi, Nuha Mohammad, Nazreen, Syed, Zabin, Sami A. |
| Předmět: |
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| Zdroj: |
Journal of Essential Oil-Bearing Plants; Oct2023, Vol. 26 Issue 5, p1101-1122, 22p |
| Abstrakt: |
This work focuses on evaluating the chemical composition, biological potency and in silico computational studies of selected identified molecules in the essential oils obtained from Nepeta deflersiana (Lamiaceae) and Marrubium vulgare (Lamiaceae) plants. The essential oils were extracted using Clevengertype system and analyzed by gas chromatography-based techniques (GC-FID and GC-MS) using a HP-5MS column. Twenty constituents were identified in Nepeta deflersiana essential oil (NDEO) whereas forty-three were identified in Marrubium vulgare essential oil (MVEO) representing 99.55% and 94.75% of the total essential oil composition, respectively. 4aa,7a,7aa Nepetalactone was the major component in both NDEO (77.79%) and MVEO (63.67%) and first time reported in Marrubium genus by our group. The antioxidant activity has been determined using DPPH, TEAC and FRAP methods and expressed as µmol Trolox equivalent/g. All the spectrophotometric assays proved the strong radical scavenging and reducing power of MVEO. The antimicrobial activities revealed moderate to significant antibacterial potential and no inhibitory effect was observed against C. albicans. NDEO showed the highest effectiveness against S. pneumoniae (24 mm zone of inhibition, MIC 25 µg/mL). Cytotoxicity assessment against two breast cancers (MCF-7 and MDA-MB-231) and one prostate cancer cell (PC-3) revealed that MVEO was more cytotoxic than NDEO to the tested breast cell lines (IC50 = 30.11 for MCF-7 and 68.25 µg/mL for MDAMB-231) while moderately inhibited prostate cancer cells (IC50 = 135.60 µg/mL). In silico computation study for selected ingredients suggested that they have drug-likeness properties. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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