Aminoacyl-tRNA synthetase interactions in SARS-CoV-2 infection.

Autor: Khan, Debjit, Fox, Paul L.
Předmět:
Zdroj: Biochemical Society Transactions; Dec2023, Vol. 51 Issue 6, p2127-2141, 15p
Abstrakt: Aminoacyl-tRNA synthetases (aaRSs) are ancient enzymes that serve a foundational role in the efficient and accurate translation of genetic information from messenger RNA to proteins. These proteins play critical, non-canonical functions in a multitude of cellular processes. Multiple viruses are known to hijack the functions of aaRSs for proviral outcomes, while cells modify antiviral responses through non-canonical functions of certain synthetases. Recent findings have revealed that severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the etiological agent of coronaviral disease 19 (COVID-19), utilizes canonical and non-canonical functions of aaRSs, establishing a complex interplay of viral proteins, cellular factors and host aaRSs. In a striking example, an unconventional multi-aaRS complex consisting of glutamyl-prolyl-, lysyl-, arginyl- and methionyl-tRNA synthetases interact with a previously unknown RNA-element in the 30-end of SARSCoV-2 genomic and subgenomic RNAs. This review aims to highlight the aaRS-SARSCoV-2 interactions identified to date, with possible implications for the biology of host aaRSs in SARS-CoV-2 infection. [ABSTRACT FROM AUTHOR]
Databáze: Complementary Index