| Abstrakt: |
Inconsistent findings have emerged from epidemiological research investigating the association between vitamin B6 and the risk of gastric cancer. To obtain a more precise assessment, we conducted a comprehensive search of published data and performed a meta-analysis. PubMed, Web of Science, EMBASE and Cochrane Library databases were systematically searched. A total of 12 studies (5 prospective cohort and 7 case–control studies) involving 5,692 cases and 814,157 participants were included in the meta-analysis. The results showed that high intake of vitamin B6 may reduce the odds of gastric cancer (OR = 0.83, 95% CI: 0.73–0.95, p=0.006). However, this association was only observed in the case– control studies (OR = 0.68, 95% CI: 0.51–0.89, p=0.006) but not in the cohort studies (RR = 1.01, 95% CI: 0.94–1.08, p=0.819). Additionally, the negative association between vitamin B6 intake and gastric cancer risk was found in the United States of America (OR = 0.71, 95% CI: 0.62–0.82, p=10−4), but not in Europe (OR = 0.88, 95% CI: 0.74–1.05, p=0.169) or the other regions (OR = 0.86, 95% CI: 0.66–1.13, p=0.280). In conclusion, there is not sufficient evidence to assume that vitamin B6 intake is associated with gastric cancer risk, which needs further confirmation. [ABSTRACT FROM AUTHOR] |
