| Autor: |
Goswami, Ritabrita, Gupta, Aarohi, Bednova, Olga, Coulombe, Gaël, Patel, Dipika, Rotello, Vincent M., Leyton, Jeffrey V. |
| Předmět: |
|
| Zdroj: |
Chemical Society Reviews; 1/7/2024, Vol. 53 Issue 1, p204-226, 23p |
| Abstrakt: |
Nuclear targeting of therapeutics provides a strategy for enhancing efficacy of molecules active in the nucleus and minimizing off-target effects. 'Active' nuclear-directed transport and efficient translocations across nuclear pore complexes provide the most effective means of maximizing nuclear localization. Nuclear-targeting systems based on nuclear localization signal (NLS) motifs have progressed significantly since the beginning of the current millennium. Here, we offer a roadmap for understanding the basic mechanisms of nuclear import in the context of actionable therapeutic design for developing NLS-therapeutics with improved treatment efficacy. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
|
