Two-Week Direct-Acting Antiviral Prophylaxis for Kidney Transplantation From Donors With Hepatitis C Viremia to Recipients Without Hepatitis C Viremia: A Small Uncontrolled Trial.

Autor: Desai, Niraj M., Leung, Sherry G., Motter, Jennifer D., Segev, Dorry L., Warren, Daniel, Durand, Christine M.
Předmět:
Zdroj: Annals of Internal Medicine; Dec2023, Vol. 176 Issue 12, p1682-1684, 8p
Abstrakt: A small uncontrolled trial conducted at Johns Hopkins investigated the safety and efficacy of a two-week direct-acting antiviral (DAA) prophylaxis for kidney transplantation from donors with hepatitis C virus (HCV) viremia to recipients without HCV viremia. The trial involved 10 kidney transplant recipients, and all 10 recipients had undetectable HCV RNA at the 12-week follow-up. One participant experienced transient liver function abnormalities, but there were no rejection events or deaths. The study suggests that a two-week DAA prophylaxis may be an effective and safe option for preventing HCV infection in kidney transplant recipients. [Extracted from the article]
Databáze: Complementary Index