| Autor: |
Lei, Josh Haipeng, Lee, Mi‐Hye, Miao, Kai, Huang, Zebin, Yao, Zhicheng, Zhang, Aiping, Xu, Jun, Zhao, Ming, Huang, Zenan, Zhang, Xin, Chen, Si, Jiaying, NG, Feng, Yuzhao, Xing, Fuqiang, Chen, Ping, Sun, Heng, Chen, Qiang, Xiang, Tingxiu, Chen, Lin, Xu, Xiaoling |
| Předmět: |
|
| Zdroj: |
Advanced Science; 12/27/2023, Vol. 10 Issue 36, p1-5, 5p |
| Abstrakt: |
The article titled "Activation of FGFR2 Signaling Suppresses BRCA1 and Drives Triple-Negative Mammary Tumorigenesis That is Sensitive to Immunotherapy" discusses the role of FGFR2 activation in promoting mammary tumorigenesis and its interaction with BRCA1. The study found that FGFR2 activation leads to epithelial-mesenchymal transition (EMT) through STAT3-MAPK signaling. Additionally, FGFR2 activation negatively regulates BRCA1 by suppressing the transcription factor YY1 mediated by the FRS2α/STAT3/MAPK pathways. The cooperation between FGFR2 activation and BRCA1 deficiency accelerates mammary tumorigenesis. The findings suggest that targeting FGFR2 signaling may be a potential therapeutic strategy for triple-negative breast cancer. [Extracted from the article] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
|
|
Nepřihlášeným uživatelům se plný text nezobrazuje |
K zobrazení výsledku je třeba se přihlásit.
|
