| Abstrakt: |
A recent study conducted at the Rocky Mountain Regional VA Medical Center in Aurora, Colorado, has shed light on the adaptations of Mycobacterium tuberculosis, the bacteria responsible for tuberculosis, during prolonged multi-drug treatment. The researchers used a novel RNA-seq method called SEARCH-TB to analyze the transcriptome of the bacteria in mice treated with standard tuberculosis drugs. They found that the bacteria underwent significant cellular adaptations, including changes in metabolism and cell wall modification, to survive the drug exposure. Surprisingly, the gene expression changes observed in vitro were largely similar to those observed in vivo, suggesting that insights from laboratory studies may be applicable to real-life situations. This research provides valuable information for the development of more effective tuberculosis treatments. [Extracted from the article] |
