Researchers from Shanghai Jiao Tong University Describe Findings in Prostate Cancer (Taurine Inhibits Ferroptosis Mediated By the Crosstalk Between Tumor Cells and Tumor-associated Macrophages In Prostate Cancer).

Předmět:	PROSTATE cancer TAURINE RESEARCH personnel MACROPHAGES ANDROGEN receptors CONNECTIVE tissue cells RETICULO-endothelial system
Zdroj:	Cancer Weekly; 1/2/2024, p1102-1102, 1p
Abstrakt:	A recent study conducted by researchers from Shanghai Jiao Tong University in China explores the role of tumor-associated macrophages (TAMs) in inhibiting the effect of ferroptosis in prostate cancer. The study reveals that TAM-secreted taurine suppresses ferroptosis by activating the Liver X receptor alpha/Stearoyl-Coenzyme A desaturase 1 (LXR alpha/SCD1) pathway. Additionally, the study uncovers a reciprocal interaction between prostate cancer cells and TAMs, mediated by TAM-secreted taurine and tumor extracellular vesicles (EVs) containing miR-181a-5p. The findings suggest that targeting taurine transport could be a promising strategy to restore sensitivity to ferroptosis in prostate cancer treatment. [Extracted from the article]
Databáze:	Complementary Index
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