| Abstrakt: |
A study conducted by researchers from the Russian Academy of Sciences in Moscow explores the inhibitory effects of oligoarginine peptides and polyamine-related compounds on nicotinic acetylcholine receptors (nAChRs). The researchers found that oligoarginine peptides, known for their cell-penetrating properties, also act as inhibitors of nAChRs. They tested various polycationic compounds and found that cyclo'R8, a disulfide-fixed oligoarginine peptide, displayed similar inhibitory activity to octa-arginine (R8) against a9a10 nAChR. The study suggests that these compounds could potentially be used in the development of analgesics to reduce neuropathic pain. [Extracted from the article] |
