| Abstrakt: |
A research study conducted at Sun Yat-sen University in Guangzhou, China, explored the impact of radiation on astrocytes and mitochondria. The study found that radiation exposure led to astrocytic hyperactivation and mitochondrial hyperfunction, resulting in reduced cell proliferation and increased oxidative metabolite production. However, treatment with a specific TSPO ligand called FGIN-1-27 restored mitochondrial function, reduced oxidative metabolite production, mitigated astrocyte hyperactivity, and restored cell proliferative capacity. The findings suggest that TSPO ligands could be a promising therapeutic strategy for mitigating radiation-induced astrocyte dysfunction, with potential clinical implications for the treatment of brain injury caused by radiotherapy. [Extracted from the article] |
